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Journal of Zhejiang University. Medical sciences ; (6): 315-318, 2006.
Article in Chinese | WPRIM | ID: wpr-332152

ABSTRACT

<p><b>OBJECTIVE</b>To measure the plasma levels of von Willebrand factor (vWF) and nitric oxide (NO) in patients with metabolic disorders and to study their relationships with the disease.</p><p><b>METHODS</b>The plasma levels of vWF and NO were determined in patients with metabolic syndrome (MS group, n=36), patients with 1 - 2 metabolic disorders (MD group, n=43) and normal subjects (control group, n=30).</p><p><b>RESULT</b>The plasma vWF level was higher in MS group than that in MD group (P <0.05) and in control group (P <0.001); the vWF level in MD group was higher than that in control group (P <0.05). The NO level was lower in MS group and in MD group than that in control group (both P<0.05), while the difference between MS and MD groups was not statistically significant (P >0.05). Multiple stepwise regression showed that vWF level was correlated with systolic BP (SBP), diastolic BP(DBP) and pulse BP; that NO level was correlated with BMI, SBP and TG.</p><p><b>CONCLUSION</b>Multiple metabolic disorders of metabolic syndrome may injure endothelial cells, and the degree of endothelial cell injury seems to be correlated with the BMI, SBP, DBP, pulse BP and TG.</p>


Subject(s)
Female , Humans , Male , Middle Aged , Blood Pressure , Body Mass Index , Endothelium, Vascular , Pathology , Metabolic Syndrome , Blood , Nitric Oxide , Blood , Pulse , von Willebrand Factor , Metabolism
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